Systemic Treatments

Treatments Available by Prescription

Systemic treatments are treatments that enter into the body’s systems. These treatments are taken either orally or are injected. They are available by prescription only. Systemic treatments may be used in combination with topical or phototherapy treatments. Systemic treatments are used when symptoms range from moderate to severe.

Methotrexate: This medication slows the cell turnover by suppressing the immune system. Methotrexate can be taken orally or injected. Patients that are prescribed Methrotrexate will be monitored closely by a doctor because of the possibility of liver damage.

Retinoids: A retinoid is a compound with a vitamin A-like quality. This is commonly prescribed for severe cases of psoriasis or for cases that have not responded to other treatments. This product may cause birth defects, so a woman must protect herself against pregnancy up to 3 years after taking this product.

Cyclosporine: Like Methotrexate, this drug slows the rapid turnover of skin cells. It is taken orally and provides quick relief; however, as soon as treatment is stopped, the symptoms will return. Patients will be monitored closely because of the effect on kidney function and the risk of high blood pressure.

6-Thioguanine: This drug is as effective as Methrotrexate and Cyclosporine. There are few side effects, but there is risk of developing anemia. 6-Thioguanine induces cell cycle arrest. This is beneficial because of the high rate of cell reproduction in a person with psoriasis.

Biologic Response Modifiers: These medications are made from proteins produced by living cells instead of chemicals. Biologics interfere with the over-production of skin cells and inflammation. This new grouping of medications are administered through injection. This approach is fairly new, so the effects are not fully understood; therefore, patients need to be carefully observed by a doctor.

Antibiotics: These medications are generally not given to treat psoriasis; however, they may be used to treat an infection that may trigger an outbreak.